> In Vitro siRNA Transfection Reagents

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In Vitro siRNA Transfection Reagents:

Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, has a well-defined structure: a short (usually 21-nt) double strand of RNA (dsRNA) with 2-nt 3' overhangs on either end. siRNAs can be introduced into cells by various transfection methods to bring about the specific knockdown of a gene of interest. Essentially any gene of which the sequence is known can thus be targeted based on sequence complementarity with an appropriately tailored siRNA. This has made siRNAs an important and indispensable tool for gene function and drug target validation studies in the post-genomic era.

While liposome or polymer reagents often give very good DNA delivery efficacy, they often failed to efficiently drive siRNA into mammalian cells due to the length of the siRNA anionic segment that is too short to maintain electrostatic cohesion with the cationic lipids or polycationic polymer. We modified the liposome and polymer by addition of specific pre-screened hydrophobic groups which confers the pH dependent conformational changes (PDCC) at physiological pH condition and greatly stabilizes siRNA lipolplex or polyplex.

Based on our unique and proprietary “PDCC” technology, currently we are developing and manufacturing the following four siRNA transfection reagents, which show distinct transfection characteristics with the leading products in the market.

siRNA Transfection Reagent Selection Chart.

Reagents

Features

Transfection Type

Toxicity

PepMute™

- Exceptional good for siRNA transfection
- OK for DNA/siRNA co-transfection

siRNA
DNA/siRNA

++

GenMute™

- Exceptional good for siRNA transfection
- Excellent for DNA/siRNA co-transfection

siRNA
DNA/siRNA

++

PowerFect™

- OK for siRNA transfection
- Excellent for DNA transfection
- Excellent for DNA/siRNA co-transfection

DNA
DNA/siRNA

+

PepMute™ Plus

- Exceptional good for siRNA transfection
- Excellent for DNA/siRNA co-transfection

siRNA
DNA/siRNA

++

 



Catalog # Product Name+ Price
SL100570

GenJet™ In Vitro siRNA Transfection Reagent (Ver. II)

GenJet™ In Vitro siRNA Transfection Reagent (Ver. II) Description: GenJet™ siRNA Transfection Reagent, a...
$288.00

... more info

SL100573

GenJet™ Transfection Buffer (5x )

GenJet™ Transfection Buffer (5x ) Description: GenJet™ Transfection Buffer was formulated for GenJet™...
$39.00

... more info

SL100568

GenMute™ siRNA Transfection Reagent

GenMute™ siRNA Transfection Reagent Description: GenMute™ Reagent is a novel biodegradable non-liposomal...
$198.00

... more info

SL100572

GenMute™ Transfection Buffer (5x )

GenMute™ Transfection Buffer (5x ) Description: GenMute™ Transfection Buffer was formulated for GenMute™...
$39.00

... more info

SL100571

PepMute™ Plus siRNA Transfection Reagent

PepMute™ Plus siRNA Transfection Reagent Description: PepMute™ Plus siRNA & DNA Transfection Reagent is...
$368.00

... more info

SL100566

PepMute™ siRNA Transfection Reagent

PepMute™ siRNA Transfection Reagent Description: PepMute™ siRNA Transfection Reagent, formulated from...
$198.00

... more info

SL100575

PepMute™ Transfection Buffer (5x )

Description: PepMute™ Transfection Buffer (5x ) was formulated for PepMute™ siRNA Transfection Reagent and...
$39.00

... more info

SL100569

PowerFect™ In Vtro siRNA Transfection Reagent (Ver. II)

PowerFect™ In Vtro siRNA Transfection Reagent (Ver. II) Description: Powerfect™ siRNA Transfection...
$288.00

... more info

SL100574

PowerFect™ Transfection Buffer (5x )

PowerFect™ Transfection Buffer (5x ) Description: PowerFect™ Transfection Buffer (5x ) was formulated for...
$39.00

... more info



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