Product Category:
Human Adenovirus Type5 (dE1/E3) expressing 5' AMP-activated protein kinase (AMPK),
dominant negative format under a CMV promoter with co-expression of a reporter
GFP under a separate CMV promoter.
5' AMP-activated protein kinase or AMPK or 5' adenosine monophosphate-activated
protein kinase is an enzyme that plays a role in cellular energy homeostasis. It
consists of three subunits that together make a functional enzyme, conserved
from yeast to humans. It is expressed in a number of tissues, including the
liver, brain, and skeletal muscle. The net effect of AMPK activation is
stimulation of hepatic fatty acid oxidation and ketogenesis, inhibition of
cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of
adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid
oxidation and muscle glucose uptake, and modulation of insulin secretion by
pancreatic beta-cells.
AMPK dominant negative form is used to genetically block effects of AMPK.
