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Nucleotide and amino acid identities between rodent and other AAV capsids

 

AAV-mo.1 AAV-ra.1 AAV-1 AAV-2 AAV-hu.2 AAV-3a AAV-4 AAV-5 AAV-7 AAV-8 AAV-9 Avian Snake
% Amino acid identity
AAV-mo.1 100 58 56 56 56 55 51 53 56 56 56 50 50
AAV-ra.1 58 100 52 52 52 50 46 58 52 52 52 47 48
% Nucleotide identity
AAV-mo.1 100 60 59 58 59 58 56 58 58 59 58 61 53
AAV-ra.1 60 100 60 59 59 58 56 68 60 61 60 60 51

Amino acid sequences of capsids that represent each clade of AAV are shown. AAV-1 (GenBank accession NC_002077) represents clade A. AAV-2 (GenBank accession AF043303) represents clade B. AAV-hu.2 (GenBank accession AY530585) is a hybrid between AAV-2 and AAV-3 capsid sequences and represents clade C. AAV-7 (GenBank accession AF513851) represents clade D. AAV-8 (GenBank accession AF513852) represents clade E. AAV-9 (GenBank accession AX753250) represents clade F. AAVs that have not been assigned clade designations but represent distinct lineages based on taxonomic analysis include AAV-3a (GenBank accession NC_001729), AAV-4 (GenBank accession NC_001829), AAV-5 (GenBank accession AF085716), avian AAV (GenBank accession AY629582), and snake AAV (GenBank accession AY349010). Capsid amino acid sequences within a clade are at least 85% identical to each other.

 

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