AAV-mo.1 | AAV-ra.1 | AAV-1 | AAV-2 | AAV-hu.2 | AAV-3a | AAV-4 | AAV-5 | AAV-7 | AAV-8 | AAV-9 | Avian | Snake | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
% Amino acid identity | |||||||||||||
AAV-mo.1 | 100 | 58 | 56 | 56 | 56 | 55 | 51 | 53 | 56 | 56 | 56 | 50 | 50 |
AAV-ra.1 | 58 | 100 | 52 | 52 | 52 | 50 | 46 | 58 | 52 | 52 | 52 | 47 | 48 |
% Nucleotide identity | |||||||||||||
AAV-mo.1 | 100 | 60 | 59 | 58 | 59 | 58 | 56 | 58 | 58 | 59 | 58 | 61 | 53 |
AAV-ra.1 | 60 | 100 | 60 | 59 | 59 | 58 | 56 | 68 | 60 | 61 | 60 | 60 | 51 |
Amino acid sequences of capsids that represent each clade of AAV are shown. AAV-1 (GenBank accession NC_002077) represents clade A. AAV-2 (GenBank accession AF043303) represents clade B. AAV-hu.2 (GenBank accession AY530585) is a hybrid between AAV-2 and AAV-3 capsid sequences and represents clade C. AAV-7 (GenBank accession AF513851) represents clade D. AAV-8 (GenBank accession AF513852) represents clade E. AAV-9 (GenBank accession AX753250) represents clade F. AAVs that have not been assigned clade designations but represent distinct lineages based on taxonomic analysis include AAV-3a (GenBank accession NC_001729), AAV-4 (GenBank accession NC_001829), AAV-5 (GenBank accession AF085716), avian AAV (GenBank accession AY629582), and snake AAV (GenBank accession AY349010). Capsid amino acid sequences within a clade are at least 85% identical to each other.