ATGGCTGCCGATGGTTATCTTCCAGATTGGCTCGAGGACAACCTCTCTGAGGGCATTCGCGAGTGGTGGGACCTGAAACCTGGAGCCCCCAAGCCCAAGGCCAACCAGCAGAAGCAGGACGACGGCCGGGGTCTGGTGCTTCCTGGCTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGGGAGCCCGTCAACGCGGCGGACGCAGCGGCCCTCGAGCACGACAAGGCCTACGACCAGCAGCTCAAAGCGGGTGACAATCCGTACCTGCGGTATAACCACGCCGACGCCGAGTTTCAGGAGCGTCTGCAAGAAGATACGTCTTTTGGGGGCAACCTCGGGCGAGCAGTCTTCCAGGCCAAGAAGAGGGTACTCGAACCTCTGGGCCTGGTTGAAGAAGGTGCTAAGACGGCTCCTGGAAAGAAGAGACCGTTAGAGTCACCACAAGAGCCCGACTCCTCCTCAGGAATCGGCAAAAAAGGCAAACAACCAGCCAAAAAGAGACTCAACTTTGAAGAGGACACTGGAGCCGGAGACGGACCCCCTGAAGGATCAGATACCAGCGCCATGTCTTCAGACATTGAAATGCGTGCAGCACCGGGCGGAAATGCTGTCGATGCGGGACAAGGTTCCGATGGAGTGGGTAATGCCTCGGGTGATTGGCATTGCGATTCCACCTGGTCTGAGGGCAAGGTCACAACAACCTCGACCAGAACCTGGGTCTTGCCCACCTACAACAACCACTTGTACCTGCGGCTCGGAACAACATCAAACAGCAACACCTACAACGGATTCTCCACCCCCTGGGGATACTTTGACTTTAACAGATTCCACTGTCACTTCTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGACTACGACCAAAAGCCATGCGCGTTAAAATCTTCAATATCCAAGTTAAGGAGGTCACAACGTCGAACGGCGAGACTACGGTCGCTAATAACCTTACCAGCACGGTTCAGATATTTGCGGACTCGTCGTATGAGCTCCCGTACGTGATGGACGCTGGACAAGAGGGAAGTCTGCCTCCTTTCCCCAATGACGTCTTCATGGTGCCTCAATATGGCTACTGTGGCATTGTGACTGGCGAAAATCAGAACCAGACGGACAGAAATGCTTTCTACTGCCTGGAGTATTTTCCTTCACAAATGCTGAGAACTGGCAATAACTTTGAAATGGCTTACAACTTTGAGAAGGTGCCGTTCCACTCAATGTATGCTCACAGCCAGAGCCTGGACAGACTGATGAATCCCCTCCTGGACCAGTACCTGTGGCACTTACAGTCGACCACCTCTGGAGAGACTCTGAATCAAGGCAATGCAGCAACCACATTTGGAAAAATCAGGAGTGGAGACTTTGCCTTTTACAGAAAGAACTGGCTGCCTGGGCCTTGTGTTAAACAGCAGAGATTCTCAAAAACTGCCAGTCAAAATTACAAGATTCCTGCCAGCGGGGGCAACGCTCTGTTAAAGTATGACACCCACTATACCTTAAACAACCGCTGGAGCAACATAGCGCCTGGACCTCCAATGGCAACAGCTGGACCTTCAGATGGGGACTTCAGCAACGCCCAGCTCATCTTCCCTGGACCATCAGTCACCGGAAACACAACAACCTCAGCAAACAATCTGTTGTTTACATCAGAAGAAGAAATTGCTGCCACCAACCCAAGAGACACGGACATGTTTGGTCAGATTGCTGACAATAATCAGAATGCTACAACTGCTCCCATAACCGGCAACGTGACTGCTATGGGAGTGCTTCCTGGCATGGTGTGGCAAAACAGAGACATTTACTACCAAGGGCCAATTTGGGCCAAGATCCCACACGCGGACGGACATTTTCATCCTTCACCGCTAATTGGCGGTTTTGGACTGAAACATCCGCCTCCCCAGATATTTATCAAAAACACCCCCGTACCTGCCAATCCTGCGACAACCTTCACTGCAGCCAGAGTGGACTCTTTCATCACACAATACAGCACCGGCCAGGTCGCTGTTCAGATTGAATGGGAAATCGAAAAGGAACGCTCCAAACGCTGGAATCCTGAAGTGCAGTTTACTTCAAACTATGGGAACCAGTCTTCTATGTTGTGGGCTCCCGATACAACTGGGAAGTATACAGAGCCGCGGGTTATTGGCTCTCGTTATTTGACTAATCATTTGTAA
Adeno-associated Virus (AAV) - 2. page
Deletion of the B-B’ or C-C’ in AAV ITR has a minimal impact on AAV production but increases transgene expression
1. ITR Structure and Function• ITRs are crucial: ITRs are key elements in AAV vectors, serving as origins of replication, and are essential for viral genome replication, packaging into capsids, […]