Retinal gene therapy with adeno-associated viral (AAV) vectors is safe and effective in humans. However, AAV’s limited cargo capacity prevents its application to therapies of inherited retinal diseases due to […]
Adeno-associated Virus (AAV) - 13. page
AAV-CMV-OptoSTIM1 Ready to Package
AAV-CMV-OptoSTIM1 Ready to Package
AAV-CMV-pHuji Ready to Package
AAV-CMV-pHuji Ready to Package
AAV-CMV-saCas9-U6-sgRNA(Scramble) Ready to Package
AAV-CMV-saCas9-U6-sgRNA(Scramble) Ready to Package
AAV-EF1a-DIO-hChR2(H134R)-YFP-WPRE Ready to Package
AAV-EF1a-DIO-hChR2(H134R)-YFP-WPRE Ready to Package
AAV-mediated gene delivery of BDNF or GDNF is neuroprotective in a model of Huntington disease.
Huntington disease (HD) is a neurodegenerative disorder that results in the progressive loss of GABAergic medium spiny projection neurons in the striatum. Neurotrophic factors have demonstrated neuroprotective actions on striatal […]
Specific AAV Serotypes Stably Transduce Hippocampal and Cortical Cultures with High Efficiency and Low Toxicity
Most current methods of gene delivery for primary cultured hippocampal neurons are limited by toxicity, transient expression, the use of immature neurons, and/or low efficiency. We performed a direct comparison […]
Differential Effects of AAV-BDNF and AAV-NTF3 in the Deafened Adult Guinea Pig Ear
Intracochlear neomycin administration resulted in a complete loss of hair cells and supporting cells in the basal turn, forming a flat epithelium. A few looping auditory fibers are seen in […]