Adeno-associated Virus (AAV) - 14. page
AAV-mediated gene delivery of BDNF or GDNF is neuroprotective in a model of Huntington disease.
Huntington disease (HD) is a neurodegenerative disorder that results in the progressive loss of GABAergic medium spiny projection neurons in the striatum. Neurotrophic factors have demonstrated neuroprotective actions on striatal […]
Specific AAV Serotypes Stably Transduce Hippocampal and Cortical Cultures with High Efficiency and Low Toxicity
Most current methods of gene delivery for primary cultured hippocampal neurons are limited by toxicity, transient expression, the use of immature neurons, and/or low efficiency. We performed a direct comparison […]
Differential Effects of AAV-BDNF and AAV-NTF3 in the Deafened Adult Guinea Pig Ear
Intracochlear neomycin administration resulted in a complete loss of hair cells and supporting cells in the basal turn, forming a flat epithelium. A few looping auditory fibers are seen in […]
A Novel Synthetic AAV Capsid 8BP2 for Efficient Transduction of Retinal Bipolar Cells
The map of AAV serotype 8BP2
Full Sequence of Ace2N-4AA-mNeon, A Novel Calcium Sensor
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AAV–BDNF mediated attenuation of quinolinic acid-induced neuropathology and motor function impairment
Maintenance and plasticity of striatal neurons is dependant on brain-derived neurotrophic factor (BDNF), which is depleted in the Huntington’s disease striatum due to reduced expression and disrupted corticostriatal transportation. In […]
Comparative Analysis of Cesium Chloride- and Iodixanol-Based Purification of Recombinant Adeno-Associated Viral Vectors for Preclinical Applications.
Cesium chloride (CsCl)- and iodixanol-based density gradients represent the core step in most protocols for serotype-independent adeno-associated virus (AAV) purification established to date. However, despite controversial reports about the purity […]