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A Wide Range of AAV Capsids Available
SignaGen maintains an extensive AAV capsid collection comprising more than 146 naturally occurring, engineered, and synthetic AAV capsid plasmids. This diverse library spans a broad spectrum of serotypes and rationally designed variants, enabling precise selection of capsids optimized for specific tissues, cell types, and experimental objectives. All capsid viral plasmids in this collection are fully constructed and optimized with a dual p5 promoter configuration, comprehensively sequenced via whole-plasmid sequencing (WPS), and rigorously verified to ensure accuracy and performance. By integrating well-characterized natural isolates with next-generation engineered and synthetic capsids, SignaGen supports advanced vector discovery, tropism screening, and translational research. This comprehensive capsid portfolio provides researchers with exceptional flexibility to tailor AAV vectors for enhanced transduction efficiency, specificity, and overall performance across both in vitro and in vivo applications.
Can’t find it off-the-shelf? We offer custom AAV capsid construction, contact us at info@signagen.com
Naturally Occurring AAV Capsid Viral Plasmids We Carry
| AAV1 | AAV2 | AAV3 | AAV4 | AAV5 | AAV6 |
| AAV7 | AAV8 | AAVrh8 | AAV9 | AAV10 | AAV11 |
| AAv12 | AAV13 | AAVrh74 |
Synthetic Capsid Viral Plasmids We Carry
| AAV CAPSID VARIANT | ORIGINAL SEROTYPE | REGION MUTATED | MUTATION TYPE | AA POSITION | RESIDUES | REPORTED TROPISM PREFERENCE | ||
| AAV1-X1 | AAV1 | VR-VIII | Insertion | 588 | ARQMDL | CNS (endothelial cells), human brain endothelial cells | ||
| AAV1RX | AAV1 | VR-I | Insertion | 268 | G from AAVrh.10 | CNS (neurons, glia, endothelial cells, with neuronal bias) | ||
| Substitution | 263-266, 269-270, 274 | SAST>NGTS, AS>ST, H>T (from AAVrh.10) | ||||||
| AAV-BR1 | AAV2 | VR-VIII | Insertion | 588 | NRGTEWD | CNS (endothelial cells and neurons), spinal cord, liver de-targeted, human brain endothelial cells | ||
| rAAV2-retro | AAV2 | VR-VIII | Insertion | 587 | LADQDYTKTA | CNS, spinal cord | ||
| Substitution | 382, 708 | N>D, V>I | ||||||
| 7m8 | AAV2 | VR-VIII | Insertion | 587 | LALGETTRP | Eye (RGC, Müller cells, amacrine cells, bipolar cells, rods, cones, and RPE (mouse). Photoreceptors but not RPE (cynomolgus macaque)) | ||
| K912 | AAV2 | VR-VIII | Insertion | 588 | LAPDSTTRSA flanked by linker sequences LA and A | Eye (photoreceptors and RPE (canines). Rods, cons, RGC and Müller glia (marmoset, cynomolgus macaque)) | ||
| AAV2-NSSRDLG | AAV2 | VR-VIII | Insertion | 588 | NSSRDLG | Heart | ||
| AAV r3.45 | AAV2 | VR-VIII | Insertion | 587 | LATQVGQKTA | CNS (neural stem cells), human neural stem cells | ||
| AAV r3.45 | Cap | Substitution | 719 | V>M | ||||
| AAV-GMN | AAV2 | VR-VIII | Insertion | 587 | GMNAFRA | CNS | ||
| AAV-PFG | AAV2 | VR-VIII | Insertion | 587 | WPFYGTP | CNS | ||
| AAV-QPE | AAV2 | VR-VIII | Insertion | 587 | QPEHSST | CNS | ||
| AAV-VNT | AAV2 | VR-VIII | Insertion | 587 | VNTANST | Lung | ||
| AAV2-ESGHYGF | AAV2 | VR-VIII | Insertion | 588 | ESGHYGF | Lung (endothelial cells) | ||
| AAV2-CVGSPCG | AAV2 | VR-VIII | Insertion | 588 | CVGSPCG | FVB/N mouse | ||
| AAV2-GEC | AAV2 | VR-VIII | Insertion | 588 | QVLVYRE | Kidney glomerular endothelial cells | ||
| Li-A | AAV2 | [VR-I], [VR-IV], [VR-V] | Substitution | [263, 444], [450-452, 454-455, 459, 461], [492-494, 499-500] | [Q>A, Y>F], [TPS>SEG, TT>SL, R>S, Q>G], [SAD>DGE, EY>DF] | C57BL/6J and BALB/c mouse | ||
| Li-C | AAV2 | [VR-I], [VR-V] | Substitution | [263], [500, 503, 507] | [Q>A], [Y>F, T>P, K>T] | C57BL/6J and BALB/c mouse | ||
| MNM004 | AAV2 | VR-VIII | Insertion | 587 | VMSVLLVDTDATQQ | Rat | ||
| MNM023 | AAV2 | VR-VIII | Insertion | 587 | QQIAAGPTEGAPSV | Rat | ||
| MNM008 | AAV2 | VR-VIII | Insertion | 587 | SFTSPLHKNENTVS | Rat | ||
| MNM009 | AAV2 | VR-VIII | Insertion | 587 | FSKVSAETQASPPE | Rat | ||
| MNM017 | AAV2 | VR-VIII | Insertion | 587 | SIPGFPAEGSIPLP | Rat, rat and human cells in vitro | ||
| AAV2.5 | AAV2 | VR-I | Insertion | 265 | T | Sprague-Dawley rat, cynomolgus macaque | ||
| [VR-I], [VR-IX] | Substitution | [263], [705, 708, 716] | [Q>A], [N>A, V>A, T>N] (from AAV1) | |||||
| AAV2G9 | AAV2 | [VR-IV], [VR-V] | Substitution | [464, 467, 469, 470, 471, 472, 474], [500, 501] | [Q>V, A>P, D>N, I>M, R>A, D>V, S>G], [Y>F, S>A] | BALB/c mouse | ||
| AAV2i8 | AAV2 | VR-VIII | Substitution | 585-590 | RGNRQA>QQNTAP from AAV8 | BALB/c mouse | ||
| AAV2i8G9 | AAV2i8 | [VR-IV], [VR-V] | Substitution | [464, 467, 469, 470, 471, 472, 474], [500, 501] | [Q>V, A>P, D>N, I>M, R>A, D>V, S>G], [Y>F, S>A] | BALB/c mouse | ||
| AAV3B-GA | AAV3B | VR-I | Substitution | 265 | G>A | C57BL/6 mouse | ||
| AAV4.18 | AAV4 | [VR-V], [VR-VIII] | Substitution | [492, 503], [585] | [K>E, K>E], [N>S] | BALB/c mouse, African green monkey kidney cells in vitro | ||
| AAV(ShH10) | AAV6 | Mutation | N451D | Müller Glia (Retina) and Supporting Cells (Inner Ear) | ||||
| AAV-PHP.B | AAV9 | VR-VIII | Insertion | 588 | TLAVPFK | C57BL/6J, FVB/NJ, 129S1/SvlmJ, SJL/J, AKR/J and DBA/2J mouse, Sprague-Dawley rat (not in BALB/cJ, BALB/cByJ, A/J, NOD/ShiLtJ, NZO/HILtJ, C3H/HeJ or CBA/J mouse) | ||
| AAV-PHP.eB | AAV-PHP.B | VR-VIII | Substitution | 587-588 | AQ>DG | C57BL/6J, C57BL/6N, 129T2/SvEmsJ mouse, Fisher and Long-Evans rat | ||
| AAV.CAP-B10 | AAV-PHP.eB | VR-IV | Substitution | 453-459 | NGSGQNQ>DGAATKN | C57BL/6J mouse, marmoset | ||
| AAV.CAP-B22 | AAV-PHP.eB | VR-IV | Substitution | 453-459 | NGSGQNQ>DGQSSKS | C57BL/6J mouse, marmoset | ||
| AAV-PHP.B2 | AAV9 | VR-VIII | Insertion | 588 | SVSKPFL | C57BL/6J mouse | ||
| AAV-PHP.B3 | AAV9 | VR-VIII | Insertion | 588 | FTLTTPK | C57BL/6J mouse | ||
| AAV-PHP.A | AAV9 | VR-VIII | Insertion | 588 | YTLSQGW | C57BL/6J mouse | ||
| AAV-PHP.V1 | AAV9 | VR-VIII | Insertion | 588 | TALKPFL | C57BL/6J and FVB/NJ mouse, human cells in vitro | ||
| AAV-PHP.V2 | AAV9 | VR-VIII | Insertion | 588 | TTLKPFL | C57BL/6J mouse | ||
| AAV-PHP.B4 | AAV9 | VR-VIII | Insertion | 588 | TLQIPFK | C57BL/6J mouse | ||
| AAV-PHP.B7 | AAV9 | VR-VIII | Insertion | 588 | SIERPFK | C57BL/6J mouse | ||
| AAV-PHP.B8 | AAV9 | VR-VIII | Insertion | 588 | TMQKPFI | C57BL/6J mouse | ||
| AAV-PHP.B5 | AAV9 | VR-VIII | Insertion | 588 | TLQLPFK | C57BL/6J mouse | ||
| AAV-PHP.B6 | AAV9 | VR-VIII | Insertion | 588 | TLQQPFK | C57BL/6J mouse | ||
| AAV-PHP.N | AAV9 | VR-VIII | Insertion | 588 | TLAVPFS | C57BL/6J and FVB/NJ mouse | ||
| AAV-PHP.N | Substitution | 589-590 | AQ>NP | |||||
| AAV-PHP.AX | AAV-PHP.eB | VR-IV | Insertion | 452-458 | NTGSPYE | C57BL/6J, DBA/2J and FVB mouse | ||
| AAV-PHP.C1 | AAV9 | VR-VIII | Insertion | 588 | RYQGDSV | C57BL/6J and BALB/cJ mouse | ||
| AAV-PHP.C2 | AAV9 | VR-VIII | Insertion | 588 | WSTNAGY | C57BL/6J and BALB/cJ mouse | ||
| AAV-PHP.X1 | AAV9 | VR-VIII | Insertion | 588 | ARQMDL | C57BL/6J, BALB/cJ, FVB/NJ and CBA/J mouse, human cells in vitro | ||
| AAV-PHP.X1.1 | AAV-PHP.X1 | VR-IV | Substitution | 453-459 | NGSGQNQ>DGAATKN | C57BL/6J mouse, Lister Hooded rat, human cells in vitro and ex vivo, southern pig-tailed macaque ex vivo, rhesus macaque (not marmoset) | ||
| AAV-PHP.X1.4 | AAV-PHP.X1.1 | VR-I | Substitution | 272 | N>A | C57BL/6J mouse | ||
| AAV-PHP.X1.5 | AAV-PHP.X1.1 | VR-V | Substitution | 503 | W>A | C57BL/6J mouse | ||
| AAV9.47 | AAV9 | Cap, VR-IV, VR-VII, VR-VIII | Substitution | 414, 453, 557, 582 | S>N, G>D, K>E, T>I | BALB/c mouse | ||
| AAV-AS | AAV9.47 | Cap | Insertion | 138 | 19xA | C57BL/6J mouse, cat | ||
| AAV.CAP-Mac | AAV9 | VR-VIII | Insertion | 588 | LNTTKPI | C57BL/6J, BALB/cJ and DBA/2J mouse, marmoset, rhesus macaque, African green monkey, human cells in vitro | ||
| AAV.CAP-C2 | AAV9 | VR-VIII | Insertion | 588 | ENHTKND | Marmoset, rhesus macaque | ||
| AAV-F | AAV9 | VR-VIII | Insertion | 588 | FVVGQSY | C57BL/6J and BALB/c mouse, human cells in vitro | ||
| 9P03 | AAV9 | VR-VIII | Insertion | 588 | TTEKPWL | C57BL/6J mouse | ||
| 9P08 | AAV9 | VR-VIII | Insertion | 588 | TLSQPFR | C57BL/6J mouse | ||
| Substitution | 587-588 | AG>DG | ||||||
| 9P09 | AAV9 | VR-VIII | Insertion | 588 | TMDRPFK | C57BL/6J mouse | ||
| Substitution | 587-588 | AG>DG | ||||||
| 9P013 | AAV9 | VR-VIII | Insertion | 588 | GENPGRW | C57BL/6J mouse | ||
| 9P016 | AAV9 | VR-VIII | Insertion | 588 | TADKPFR | C57BL/6J mouse | ||
| Substitution | 587-588 | AG>DG | ||||||
| 9P031 | AAV9 | VR-VIII | Insertion | 588 | WPTSYDA | C57BL/6J mouse | ||
| 9P032 | AAV9 | VR-VIII | Insertion | 588 | TAIHLSS | C57BL/6J mouse | ||
| Substitution | 587-588 | AG>DG | ||||||
| 9P033 | AAV9 | VR-VIII | Insertion | 588 | TGQVTGW | C57BL/6J mouse | ||
| Substitution | 587-588 | AG>DG | ||||||
| 9P036 | AAV9 | VR-VIII | Insertion | 588 | SSSYYDA | C57BL/6J mouse | ||
| Substitution | 587-588 | AG>DG | ||||||
| 9P039 | AAV9 | VR-VIII | Insertion | 588 | TGSTTGW | C57BL/6J mouse | ||
| Substitution | 587-588 | AG>DG | ||||||
| AAV-PHP.eC | AAV9 | VR-VIII | Insertion | 588 | RYKGDSV | C57BL/6J, BALB/cJ and NOD/ShiLtJ mouse | ||
| AAV-PHP.eC | Substitution | 587-588 | AQ>SR | |||||
| AAV-PHP.S | AAV9 | VR-VIII | Insertion | 588 | QAVRTSL | C57BL/6j mouse | ||
| AAV-MaCPNS1 | AAV9 | VR-VIII | Insertion | 588 | PHEGSSR | C57BL/6J mouse, Sprague-Dawley rat, marmoset, rhesus macaque | ||
| AAV-MaCPNS2 | AAV9 | VR-VIII | Insertion | 588 | PNASVNS | C57BL/6J mouse, Sprague-Dawley rat, marmoset, rhesus macaque | ||
| AAV.cc47 | AAV9 | VR-IV | Substitution | 452-458 | GVSLGGG | Pig, C57BL/6 mouse, cynomolgus macaque | ||
| AAV-BI30 | AAV9 | VR-VIII | Insertion | 588 | NNSTRGG | C57BL/6 and BALB/cJ mouse, rat, human and mouse cells in vitro | ||
| AAV9.HR | AAV9 | VR-VI | Substitution | 527, 533 | H>Y, R>S | C57BL/6 mouse | ||
| BI-hTFR1 | AAV9 | VR-VIII | Insertion | 588 | Undisclosed | C57BL/6 mouse | ||
| AAV-Se1 | AAV9 | VR-VIII | Insertion | 588 | GNGVRSVGA | C57BL/6 and BALB/c mouse, marmoset | ||
| AAV-Se2 | AAV9 | VR-VIII | Insertion | 588 | GPGVPGRFA | C57BL/6 and BALB/c mouse, marmoset | ||
| AAVMYO | AAV9 | VR-VIII | Insertion | 588 | RGDLGLS | C57BL/6 and CBA17-SCID mouse | ||
| MyoAAV 1A | AAV9 | VR-VIII | Insertion | 588 | RGDLTTP | C57BL/6, BALB/c and DBA/2J mouse, human cells in vitro | ||
| MyoAAV 2A | AAV9 | VR-VIII | Insertion | 588 | RDGQTTL | C57BL/6 mouse, human cells in vitro | ||
| MyoAAV 2A | Substitution | 586-588 | SAQ>GPG | |||||
| MyoAAV 3A | AAV9 | VR-VIII | Insertion | 588 | RGDYVGL | C57BL/6 mouse, cynomolgus macaque | ||
| MyoAAV 4A | AAV9 | VR-VIII | Insertion | 588 | RGDYNSL | C57BL/6 mouse, cynomolgus macaque | ||
| MyoAAV 4A | Substitution | 587-588 | AQ>NS | |||||
| MyoAAV 4E | AAV9 | VR-VIII | Insertion | 588 | RGDFNNT | C57BL/6 mouse, cynomolgus macaque | ||
| MyoAAV 4E | Substitution | 586-588 | SAQ>ENR | |||||
| MyoAAV 4C | AAV9 | VR-VIII | Insertion | 588 | RGDYTSM | C57BL/6 mouse, cynomolgus macaque | ||
| MyoAAV 4C | Substitution | 586-588 | SAQ>QER | |||||
| AAV-S | AAV9 | VR-VIII | Insertion | 588 | STTLYSP | C57BL/6j mouse, cynomolgus macaque | ||
| AAV9.24 | AAV9 | VR-V | Substitution | 503 | W>R | BALB/c mouse | ||
| AAV9.45 | AAV9 | VR-VIII | Substitution | 498, 602 | N>Y, L>F | BALB/c mouse | ||
| AAV9.61 | AAV9 | VR-V | Substitution | 498 | N>I | BALB/c mouse | ||
| AAV9.68 | AAV9 | VR-V | Substitution | 504 | P>T | BALB/c mouse | ||
| AAV9-GA | AAV9 | VR-I | Substitution | 267 | G>A | C57BL/6 mouse | ||
| AAV9-GAST | AAV9 | VR-I | Substitution | 267, 269 | G>A, S>T | C57BL/6 mouse | ||
| cA2 | Chimera | Cap | DNA Shuffling | N/A | Hybrid of AAV1, AAV2 (majority of the sequence), AAV6 (VR-I), AAV8 (VR-II and III) and AAV9 (VR-IX) | BALB/c mouse | ||
| AAV2.5T | Chimera | Cap | DNA Shuffling | N/A | AA1-128 from AAV2 and 129-725 from AAV5 | Human cells in vitro | ||
| AAV2.5T | VR-VIII | Substitution | 581 | A>T | ||||
| AAVM41 | Chimera | Cap | DNA Shuffling | N/A | Hybrid of AAV1, 6, 7 and 8 | C57BL/6L and C57BL/6J mouse, rat, F1B hamster | ||
| SCH9 | Chimera | Cap | DNA Shuffling | N/A | Hybrid of AAV2, 6, 8 and 9 with the AAV2 VR-V to VR-VIII, the AAV8 5-fold pore structure and the AAV9 VR-IV | C57BL/6 mouse | ||
| AAV-B1 | Chimera | Cap | DNA Shuffling | N/A | Hybrid of AAV8 (majority of the sequence) and rh10 (some VR-IV residues) | C57BL/6 mouse, cat | ||
| AAV-KP1 | Chimera | Cap | DNA Shuffling | N/A | C-terminal as a hybrid of 7 serotypes and C-terminal from AAV3B | Mouse and human cells in FRG/N xenograft mice | ||
| AAV-LK303 | Chimera | Cap | DNA Shuffling | N/A | Hybrid of mainly AAV3B but also AAV1, 2, 4, 6, 8 and 9 | Human cells in vitro and in FRG xenograft mice | ||
| AAV-AM | AAV-LK03 | VR-I | Insertion | 265 | G | Human and mouse cells in FRG xenograft mice | ||
| AAV-DJ | Chimera | Cap | DNA shuffling | N/A | Composed primarily of AAV2, AAV8 and AAV9 | C57BL/6 mouse, human cells in vitro | ||
| AAV-ie | AAV-DJ | VR-VIII | Insertion | 589 | DGTLAVPFK | C57BL/6 mouse, human cells in vitro | ||
| AAV-DJ-X1 | AAV-DJ | VR-VIII | Insertion | 588 | ARQMDL | C57/BL6J mouse, human cells in vitro | ||
| AAV-DJ-NSS | AAV-DJ | VR-VIII | Insertion | 588 | NSSRDLG | FVB/NJ mouse | ||
| AAV-DJ-MVN | AAV-DJ | VR-VIII | Insertion | 588 | MVNNFEW | FVB/NJ mouse | ||
| Anc80 | De novo | Cap | Ancestral DNA sequence reconstruction | N/A | Most similar to AAV.rh10 (58 differing residues) | N/A | ||
| Anc80L65 | Anc80 | [VR-I], [Cap], [VR-V], [Cap], [VR-VIII], [Cap] | Substitution | [266], [313, 413], [497], [566, 580], [591], [616] | A>G, R>K, E>Q, A>T, S>N, Q>E, S>A, N>D | C57BL/6 mouse | ||
| Anc80L1533 | Anc80 | Cap | Substitution | 266 | A>G | C57BL/6 mouse | ||
| AAV9-retro | AAV9 | VR-VIII | Insertion | 587 | LADQDYTKTA | CNS, spinal cord | ||
| AAV-Rec2 | AAV8/rh10 | |||||||
| AAV-Rec2V7 | AAV-Rec2 | |||||||
| AAV9-X1.1 | AAV9 | |||||||
| AAV6.2 | AAV6 | |||||||
| AAV(Ark313) | AAV6 | |||||||
| AAV(MG1.2) | ||||||||
| AAV(M1) | ||||||||
| AAV(M2) | ||||||||
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