Feature	Details
Origin	Isolated from Rhesus Macaques (Simian origin).
Primary Receptor	AAVR (KIAA0319L) — required for entry.
Glycan Attachment	Independent of Heparin (unlike AAV2).
Primary Tropism	CNS (Neurons), Retina (Amacrine and Horizontal cells).
Peripheral Profile	Reduced Peripheral Tropism (low pick-up in liver/heart).
Clinical Focus	Tay-Sachs Disease, Parkinson’s, and Lysosomal Storage Diseases.
BBB Capability	High — can cross the Blood-Brain Barrier after systemic injection.
Unique Trait	Neuro-Precision: Stronger preference for neurons over glia than AAV8.
Seroprevalence	Very Low in humans (ideal for avoiding pre-existing immunity).