Feature	Details
Origin	Isolated from Rhesus Macaque (Simian origin).
Primary Receptor	LamR (37/67-kDa Laminin Receptor).
Co-receptors	AAVR (KIAA0319L) — the universal AAV entry factor.
Primary Tropism	Liver (Hepatocytes) — exceptionally high efficiency.
Other Tropisms	Heart, Skeletal Muscle, Retina (Photoreceptors), Pancreas.
Clinical Fame	Vector for Hemgenix (FDA-approved for Hemophilia B).
Seroprevalence	Lower than AAV2 (~20% to 40% of humans have antibodies).
Unique Trait	Non-heparin binding; crosses the blood-vessel barrier efficiently.
Speed	Very fast onset of gene expression compared to AAV2.