Feature	Details
Origin	Isolated from Rhesus Macaque (Simian origin).
Primary Receptor	AAVR (KIAA0319L) — specifically the PKD2 domain.
Co-receptors	Glycan-independent (unlike AAV9 or AAV1).
Primary Tropism	Heart (Myocardium), Skeletal Muscle, Liver.
Secondary Tropism	CNS (Neurons and Astrocytes) when delivered locally.
Clinical Focus	Muscular Dystrophy, Heart Failure, and Metabolic diseases.
Unique Trait	Highest cardiac tropism among many natural variants; low glycan binding.
Seroprevalence	Very Low in humans (~15–20% have pre-existing antibodies).