Feature	Details
Origin	Isolated from human tissue (condyloma acuminatum).
Primary Receptor	N-linked Sialic Acid.
Co-receptors	PDGFR (Platelet-Derived Growth Factor Receptor).
Primary Tropism	Liver (Hepatocytes), Lung (Airway epithelium), CNS (Astrocytes).
Clinical Fame	Vector for Roctavian (FDA-approved for Hemophilia A).
Seroprevalence	Lowest among human serotypes (~25–35% global average).
Unique Trait	Helper Virus: Naturally prefers Herpes Simplex Virus (HSV) over Adenovirus.
Divergence	Most sequence-diverse human serotype; lacks the “HSPG” binding site of AAV2.