Feature	Details
Origin	Isolated from human tissue (Adenovirus type 7 contaminant).
Variants	Two distinct isolates: AAV3A and AAV3B (differ by only 6 amino acids).
Primary Receptor	HSPG (Heparan Sulfate Proteoglycan) — but with lower affinity than AAV2.
Co-receptors	HGFR (Hepatocyte Growth Factor Receptor) and FGFR1.
Primary Tropism	Liver (Hepatocytes), Human Liver Cancer (HCC), and Cochlear Hair Cells.
Clinical Focus	Hemophilia B and Hepatocellular Carcinoma (HCC).
Unique Trait	Species Specificity: Highly efficient in human liver cells, but very poor in mouse liver cells.
Seroprevalence	Moderate to High in humans (often overlaps with AAV2 immunity).