Feature	Details
Origin	Isolated from human tissue (Adenovirus contaminant).
Primary Receptor	HSPG (Heparan Sulfate Proteoglycan).
Co-receptors	FGFR1, α-V β5 Integrin, HGFR, and CD9.
Universal Receptor	AAVR (KIAA0319L) — required for most AAV entry.
Primary Tropism	Retina, CNS, Kidney, Liver, and Vascular Smooth Muscle.
Clinical Fame	Vector for Luxturna (First FDA-approved AAV therapy).
Seroprevalence	High in humans (30% to 70% have pre-existing antibodies).
Unique Trait	Site-specific integration (AAVS1 site on Chromosome 19).