AAV11

Feature	Details
Origin	Isolated from Cynomolgus monkeys (Non-human primate).
Primary Receptor	N-linked Sialic Acid (likely α-2,3 or α-2,6).
Evolutionary Clade	Unassigned (Phylogenetically closest to AAV4 and AAV12).
Primary Tropism	CNS (Retrograde neurons & Astrocytes), Muscle, Heart.
Secondary Tropism	Kidney and Lung (limited efficiency compared to others).
Neuro-Specialty	Retrograde Transport (uptake at axons, travel to cell body).
Unique Trait	Astrocyte Specialist: Highly efficient at targeting glial cells in the brain.
Seroprevalence	Very Low in humans (ideal for avoiding pre-existing immunity).