Feature	Details
Origin	Isolated from Rhesus Macaque (Simian origin).
Primary Receptor	N-linked Sialic Acid (specifically $\alpha$2,3 and $\alpha$2,6).
Co-receptors	AAVR (KIAA0319L) — highly dependent on this universal receptor.
Primary Tropism	CNS (Neurons & Glia), Liver, Heart, Skeletal Muscle.
Clinical Fame	Used in trials for Metachromatic Leukodystrophy and Batten Disease.
BBB Capability	Excellent — rivals or exceeds AAV9 in its ability to cross the blood-brain barrier.
Seroprevalence	Very Low in humans (less than 15–20% have antibodies).
Unique Trait	Rapid Onset: Shows faster gene expression than AAV9 in many tissues.