A Guide to Selecting the Appropriate AAV Serotype

Choosing the optimal AAV serotype is critical for achieving efficient gene delivery, appropriate tissue tropism, and desired expression levels. Different capsids exhibit distinct transduction profiles depending on species, route of administration, age, and target cell type. The guide below summarizes commonly used serotypes for in vivo applications (mouse-focused). The chart below will summarize the tissue tropism and transduction of different AAV serotypes for your ease of selection.