Guidelines for Promoter Selection in AAV Cis Vectors

Helping you identify which promoter(s) to select when designing your AAV constructs. 

Key Considerations in AAV Promoter Selection

The blocks below summarize the tissue tropism and transduction characteristics of various AAV promoters to assist with your selection.

Key Notes: No AAV promoter is strictly exclusive to a particular tissue or cell type. Nevertheless, certain promoters exhibit higher transduction efficiency or expression levels in specific tissues.

Refer to “AAV Serotype Selection Guidelines”

Tissue-Specific and Cell-Specific Promoters

Brain: Neurons

Brain: Non-neuronal Cells

Ocular

Heart

Lungs

Kidneys

Pancreas

Adipose

Liver

Muscles

Vascular Endothelium

Immune System

Skin

Gastrointestinal Tract

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