-
PHONE: 1-866-918-6812
Ad-CMV-SpCas9
Product Category: Human Adenovirus Type 5 (dE1/E3) | Ad-CMV-Cas9 | Ad-CMV-SpCas9
Description:
This recombinant human adenovirus serotype 5 (E1/E3-deleted) expresses a codon-optimized SpCas9 (Streptococcus pyogenes Cas9) nuclease under the control of the CMV promoter. It is designed for efficient genome editing applications when used in combination with a guide RNA (gRNA) targeting the gene of interest.
The Type II CRISPR/Cas system is a powerful and versatile platform for targeted genome engineering. SpCas9, derived from the adaptive immune system of Streptococcus pyogenes, functions as an RNA-guided DNA endonuclease. Directed by a customizable gRNA, Cas9 introduces site-specific double-strand breaks in genomic DNA, enabling precise gene knockout, knock-in, or sequence modification.
Compared to earlier genome editing technologies such as TALENs and zinc finger nucleases (ZFNs), the CRISPR/Cas9 system offers significant advantages in ease of design, efficiency, and scalability. As a result, it has become a widely adopted tool for genome editing in both in vitro and in vivo applications.
Storage Buffer: DMEM with 2% BSA & 2.5% Glycerol
User Manual: 
Shuttle Vector Map:
CITATIONS
| Shipping Weight | 6 lbs |
|---|---|
| Unit Size | 200 µL at >1E+10 PFU/mL, 50 µL at >1E+10 PFU/mL |
Customers who bought this product also purchased…
-
SL100668LipoD293™ In Vitro DNA Transfection Reagent Original price was: $218.00.$185.00Current price is: $185.00.Add to cart This product has multiple variants. The options may be chosen on the product page
-
SL100489-MEFGenJet™ In Vitro DNA Transfection Reagent for MEFs$178.00Add to cart This product has multiple variants. The options may be chosen on the product page
-
SL100268LV-CMV-GFP-Puro$468.00Add to cart This product has multiple variants. The options may be chosen on the product page
-
SL101107Ad-CMV-Cas9(D10A)-T2A-DasherGFP$488.00Add to cart This product has multiple variants. The options may be chosen on the product page
Custom Service Solutions
Looking for a customized solution? Our end-to-end capabilities support both in vitro and in vivo applications, with rigorous quality control, scalable production processes, and expert scientific oversight at every stage.
Important updates waiting for you!
Enter your email address below and subscribe to our newsletter