AAV-Syn-httQ18 (Serotype PHP.eB)

Product Category: Pre-made recombinant AAV | AAV(PHP.eB)-Syn-httQ18 | AAV-Syn-httQ18

Description:
AAV(PHP.eB)-Syn-httQ18 is a pre-made recombinant adeno-associated virus (rAAV) packaged with the engineered PHP.eB capsid (with AAV2 ITRs) designed for neuron-specific expression of a huntingtin (HTT) protein fragment containing 18 CAG repeats (encoding glutamine, Q), representing a non-pathogenic polyglutamine (polyQ18) tract of the wild-type form. Expression is driven by the human synapsin (Syn) promoter, enabling selective and robust transgene expression in neuronal populations.

The PHP.eB capsid enables enhanced blood–brain barrier (BBB) penetration and widespread neuronal transduction following systemic delivery in mice, making it highly suitable for central nervous system (CNS) studies. The httQ18 construct serves as a baseline control for investigating huntingtin biology, allowing comparison with expanded polyglutamine variants associated with Huntington’s disease.

This vector is well-suited for neuroscience research, neuronal function studies, and in vivo CNS modeling. By restricting expression to neurons, AAV(PHP.eB)-Syn-httQ18 enables precise evaluation of wild-type HTT function and its role in neuronal physiology.

Supplied in a ready-to-use format, AAV(PHP.eB)-Syn-httQ18 provides high neuronal transduction efficiency and consistent expression for both in vitro neuronal cultures and in vivo mouse models.