AAV-Syn-hSNCA (Serotype PHP.eB)

Product Category: Pre-made recombinant AAV | AAV-Syn-hSNCA | AAV(PHP.eB)-Syn-hSNCA

Description:
AAV(PHP.eB)-Syn-hSNCA is a pre-made recombinant adeno-associated virus (rAAV) packaged in the PHP.eB capsid (with AAV2 ITRs), designed for efficient neuron-targeted expression of human alpha-synuclein (hSNCA). Expression is driven by the human synapsin (Syn) promoter, enabling selective and robust transgene expression in neuronal populations.

The PHP.eB capsid is engineered for enhanced central nervous system (CNS) transduction following systemic delivery in mice, enabling widespread neuronal gene expression across the brain and spinal cord. The encoded human SNCA gene produces alpha-synuclein, a key protein implicated in the pathogenesis of Parkinson’s disease and related synucleinopathies. Overexpression of hSNCA is widely used to model protein aggregation, Lewy body formation, and dopaminergic neurodegeneration.

This vector is well-suited for in vivo studies of neurodegenerative disease mechanisms, including alpha-synuclein aggregation, propagation, and therapeutic intervention strategies targeting synucleinopathies.

Ready-to-use format.

Titer: >1E+13 VG/mL

Size: 30 µL (Std Pack)

Storage Buffer: Sterile PBS supplemented with final 0.005% Pluronic F-68 and 200 mM NaCl

Infection Protocol:

Vector Map: