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AAV-Syn-GFP-httQ23 (Serotype 2)
Product Category: Pre-made recombinant AAV | AAV2-Syn-GFP-httQ23 | AAV-Syn-GFP-httQ23
Description:
AAV2-Syn-GFP-httQ23 is a pre-made recombinant adeno-associated virus (rAAV) packaged in serotype 2 (AAV2 capsid with AAV2 ITRs) designed for neuron-specific expression of a GFP-tagged huntingtin (HTT) protein fragment containing 23 CAG repeats (encoding glutamine, Q), representing the non-pathogenic polyglutamine (polyQ23) tract of the wild-type form. Expression is driven by the human synapsin (Syn) promoter, enabling selective and robust transgene expression in neuronal populations.
The GFP fusion allows direct visualization of HTT protein localization, intracellular trafficking, and expression patterns specifically in neurons. As a non-pathogenic control, httQ23 serves as an essential baseline comparator for studies involving mutant huntingtin variants with expanded polyglutamine repeats.
This vector is particularly well-suited for neuroscience research, neuronal protein localization studies, and in vivo modeling. By restricting expression to neurons, AAV2-Syn-GFP-httQ23 enables precise investigation of HTT biology in relevant cell types.
Supplied in a ready-to-use format, AAV2-Syn-GFP-httQ23 provides reliable neuronal transduction and consistent expression for both in vitro neuronal cultures and in vivo applications.
Titer: >1E+13 VG/mL
Size: 30 µL (Std Pack)
Storage Buffer: Sterile PBS supplemented with final 0.005% Pluronic F-68 and 200 mM NaCl
Infection Protocol: 
Vector Map:
CITATIONS
| Shipping Weight | 6 lbs |
|---|---|
| Unit Size | 30 µL at >10¹³ VG/mL, 10 µL at >10¹³ VG/mL |
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