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AAV-hSyn-RiboL1-jGCaMP8s (Serotype 1)
Product Category: Pre-made recombinant AAV; Calcium Indicator AAV; Soma-Targeted Calcium Sensor; Neuronal AAV; AAV1-hSyn-RiboL1-jGCaMP8s
Description:
AAV1-hSyn-RiboL1-jGCaMP8s is a pre-packaged recombinant adeno-associated viral (rAAV) vector in serotype 1 designed for neuron-specific, soma-targeted calcium imaging. The vector utilizes the human synapsin (hSyn) promoter to drive neuronal expression of the genetically encoded calcium indicator jGCaMP8s.
The RiboL1 soma-targeting element is fused to jGCaMP8s to preferentially localize the calcium indicator to neuronal cell bodies, thereby reducing fluorescence from axons and dendrites. This soma-restricted labeling can improve the spatial separation of individual neurons and reduce neuropil background, making the vector particularly useful for calcium imaging in densely labeled neuronal populations.
jGCaMP8s is a fast and sensitive genetically encoded calcium indicator suitable for monitoring neuronal calcium dynamics and neural activity. The vector also contains WPRE to enhance transgene expression and a bGH polyadenylation signal.
Size: 100 µL (2 x 50 µL, Std Pack)
Reconstitution Buffer: Sterile PBS supplemented with final 0.005% Pluronic F-68 and 200 mM NaCl
Infection Protocol: 
Vector Map:
CITATIONS
| Shipping Weight | 6 lbs |
|---|---|
| Unit Size | 100 (2 x 50) µL at >10¹³ VG/mL, 50 µL at >10¹³ VG/mL |
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