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AAV-hSyn-GRAB-DA2m
Description:
AAV-hSyn-GRAB-DA2m is a ready-to-package AAV vector designed for fluorescent monitoring of dopamine dynamics in neurons. The corresponding AAV cis plasmid is already available and ready for immediate AAV packaging—simply choose your desired AAV serotype to initiate production.
The human synapsin (hSyn) promoter drives neuron-selective expression of GRAB-DA2m, a second-generation genetically encoded fluorescent dopamine sensor with medium dopamine affinity. GRAB-DA2m produces a fluorescence response upon dopamine binding, enabling real-time monitoring of dopamine release and dynamics in neuronal populations.
This vector is particularly useful for studying dopaminergic signaling, dopamine release and dynamics, neural circuit activity, behavior-associated dopamine responses, and neuromodulation in cultured neurons and animal models.
Key Features:
- AAV cis plasmid: In stock and ready for immediate packaging
- AAV serotype: Customer-selectable from 146+ natural and engineered AAV capsids
- Promoter: hSyn (human synapsin)
- Sensor: GRAB-DA2m
- Sensor type: Genetically encoded fluorescent dopamine sensor
- Affinity: Medium-affinity dopamine sensor
- Applications: Real-time dopamine monitoring, dopaminergic signaling, neural circuit studies, neuromodulation, and behavioral neuroscience
- Purity: In vivo grade; suitable for tissue culture transduction and animal injection
Size: 100 µL (2 x 50 µL, Std Pack)
Reconstitution Buffer: Sterile PBS supplemented with final 0.005% Pluronic F-68 and 200 mM NaCl
Infection Protocol: 
Vector Map:
CITATIONS
| Shipping Weight | 6 lbs |
|---|---|
| Unit Size | 100 (2 x 50) µL at >10¹³ VG/mL |
| AAV Serotype | AAV1, AAV2, AAV3, AAV4, AAV5, AAV6, AAV8, AAV9, AAV(DJ), AAV(BI30), AAVrg, AAV(PHP.eB), AAV(Myo2A), AAV(BR1), Custom Serotype (Specify Below) |
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