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Off-the-shelf viral vectors for overexpression of Gaussia luciferase for in vivo imaging
Off-the-shelf viral vectors for Gaussia luciferase (Gluc) overexpression enable sensitive bioluminescent in vivo imaging using the substrate coelenterazine. Gluc produces blue light without requiring ATP, making it suitable for monitoring gene expression, cell viability, and biological processes in diverse tissues. These ready-to-use vectors—available in AdV, AAV, and LV formats—are engineered for robust expression and supplied at high titers for immediate application. They support studies such as tumor tracking, cell trafficking, biodistribution analysis, and longitudinal evaluation of therapeutic responses in preclinical animal models.
Gaussia Luciferase (Gluc)
Gaussia luciferase (GLuc) is a small, naturally secreted bioluminescent enzyme from the marine copepod Gaussia princeps that generates bright blue light (~480 nm) when reacting with coelenterazine. Because it is released into the surrounding medium, GLuc enables convenient, non-destructive measurement of gene expression from cell culture supernatants or body fluids, making it highly useful for real-time monitoring, in vivo studies, and high-throughput screening applications.
Explore our pre-made viral vectors for Gaussia luciferase overexpression, optimized for reliable performance in in vivo imaging applications.
| SKU # | Viral Vector | Unit Size | Titer |
|---|---|---|---|
| SL100307 | LV-CMV-Gluc-Puro | 25~ 50 µL | >1E+9 TU/mL |
| SL100314 | LV-CMV-hGluc-Puro | 25~ 50 µL | >1E+9 TU/mL |
| SL100345 | LV-Syn-hGluc-Puro | 25~ 50 µL | >1E+9 TU/mL |
| SL100346 | LV-CAG-hGluc-Puro | 25~ 50 µL | >1E+9 TU/mL |
| SL1003086 | LV-EF1α-hGluc-IRES-Puro | 25~ 50 µL | >1E+9 TU/mL |
| SL101720 | Ad-CMV-hGluc | 50~ 200 µL | >1E+10 PFU/mL |
| SL116005 | AAV1-CAG-hGluc | 10~ 30 µL | >1E+13 VG/mL |
| SL116006 | AAV8-CAG-hGluc | 10~ 30 µL | >1E+13 VG/mL |
| SL116007 | AAV9-CAG-hGluc | 10~ 30 µL | >1E+13 VG/mL |
Interested in custom viral vectors for in vivo imaging?
SignaGen provides custom viral vector solutions for sensitive and reliable in vivo imaging. We design and produce AAV, lentiviral, and adenoviral vectors expressing fluorescent and bioluminescent reporters (e.g., GFP, mCherry, luciferase), optimized for tissue-specific expression and strong signal output. With high-titer production and rigorous QC, our vectors support real-time visualization of gene expression, cell tracking, and disease progression in diverse in vivo models.
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