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Off-the-shelf viral vectors for overexpression of NanoLuc for in vivo imaging
Off-the-shelf viral vectors for NanoLuc overexpression enable highly sensitive bioluminescent in vivo imaging. NanoLuc is a small, ATP-independent luciferase that produces intense blue light using the substrate furimazine, allowing detection of low-level gene expression and small cell populations. These ready-to-use vectors—available in AdV, AAV, and LV formats—are engineered for robust expression and produced at high titers for immediate use. They support applications such as gene expression monitoring, cell tracking, biodistribution analysis, and evaluation of therapeutic responses in preclinical animal models.
NanoLuc (Nluc)
An engineered luciferase derived from deep-sea shrimp, NanoLuc (Nluc) is much smaller in size and approximately 100-fold brighter than firefly (fLuc) or Renilla (Rluc) luciferase. However, its blue emission spectrum limits light penetration, making it less effective for very deep-tissue imaging.
Explore our pre-made viral vectors for NanoLuc overexpression, optimized for robust performance in in vivo imaging applications.
| SKU # | Viral Vector | Unit Size | Titer |
|---|---|---|---|
| SL116218 | AAV5-CAG-NanoLuc-T2A-mCherry | 10~ 30 µL | >1E+13 VG/mL |
| SL116219 | AAV8-CMV-NanoLuc-T2A-mCherry | 10~ 30 µL | >1E+13 VG/mL |
| SL116239 | AAV9-CAG-NanoLuc-T2A-GFP | 10~ 30 µL | >1E+13 VG/mL |
| SL116240 | AAV9-CAG-NanoLuc-T2A-mCherry | 10~ 30 µL | >1E+13 VG/mL |
| SL116397 | AAV5-CAG-NanoLuc-T2A-GFP | 10~ 30 µL | >1E+13 VG/mL |
| SL116475 | AAV8-CAG-NanoLuc-T2A-mCherry | 10~ 30 µL | >1E+13 VG/mL |
Interested in custom viral vectors for in vivo imaging?
SignaGen provides custom viral vector solutions for sensitive and reliable in vivo imaging. We design and produce AAV, lentiviral, and adenoviral vectors expressing fluorescent and bioluminescent reporters (e.g., GFP, mCherry, luciferase), optimized for tissue-specific expression and strong signal output. With high-titer production and rigorous QC, our vectors support real-time visualization of gene expression, cell tracking, and disease progression in diverse in vivo models.
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