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Inducible Gene Expression
SignaGen offers a comprehensive portfolio of pre-manufactured viral vectors designed for tightly regulated, inducible gene expression in mammalian systems. In parallel, we provide full-service custom vector engineering and production using adenoviral, adeno-associated viral (AAV), and lentiviral platforms to generate inducible expression constructs optimized for specific promoters, regulatory elements, and transgenes of interest. Our scientific support team delivers detailed vector maps, induction kinetics, and empirically guided dosing recommendations to suppress basal promoter activity and minimize off-target or background expression (“leakiness”). These measures enable high dynamic range, reproducible induction, and ensure experimental fidelity in studies requiring precise temporal and quantitative control of gene expression.
Off-the-shelf viral vectors for inducible gene expression
Tet-On/Off & Cumate–CymR Systems
The Tet-On/Off system uses doxycycline to reversibly control gene expression, enabling precise induction or repression of a transgene in a dose-dependent manner. The Cumate–CymR system provides an orthogonal, small-molecule–regulated switch based on bacterial repressor biology, offering tight control and compatibility with Tet systems for dual or multiplexed regulation
Cre & FLPo recombinase systems
Cre and Flpo are site-specific recombinase systems that act as precise “genetic scissors” to control gene expression with high spatial and temporal resolution. Cre recombinase recognizes loxP sites, while Flpo—an optimized variant of the yeast-derived Flp—targets FRT sites; upon expression, these enzymes mediate deletion, inversion, or translocation of DNA segments flanked by their respective recognition sites. Using both systems together, an approach known as intersectional genetics, allows researchers to manipulate only those cells defined by the overlap of two markers (for example, cells expressing both Gene A and Gene B). This dual-recombinase strategy is widely used for generating conditional knockout models, mapping and labeling neuronal circuits, and dissecting complex developmental lineages with minimal off-target effects on the organism
Custom viral vectors for inducible gene expression
Still can’t find the viral vectors you need for inducible gene expression in our off-the-shelf inventory? We offer custom viral vector production tailored for inducible gene expression applications. Let SignaGen build your custom viral vectors, so you can stay focused on your science while we handle the vector design and production.
AAV Production Full Service — SignaGen provides comprehensive, end-to-end recombinant AAV production full services, from gene synthesis and vector construction to delivery of in vivo–grade AAV vectors. We offer high-titer and ultra-high-titer preparations at production scales of up to 100 mL, achieving titers greater than 1 × 10¹³ VG/mL.
AAV Packaging Service — SignaGen offers recombinant AAV packaging services using customer-supplied AAV cis and trans plasmids, delivering in vivo–grade preparations at high and ultra-high titers. Production scales are available up to 100 mL, with titers exceeding 1 × 10¹³ VG/mL.
Lentivirus Production Full Service — SignaGen offers comprehensive, end-to-end lentivirus production, from gene synthesis and vector construction to delivery of in vivo–grade lentiviral vectors. We provide high-titer and ultra-high-titer preparations at scales of up to 5.0 mL, achieving titers greater than 1 × 10⁹ TU/mL.
Lentivirus Packaging Service — SignaGen provides lentivirus packaging services using customer-supplied lentivector plasmids, delivering in vivo–grade preparations at high and ultra-high titers. Production scales are available up to 5.0 mL, with titers exceeding 1 × 10⁹ TU/mL.
Interested in custom viral vectors for inducible gene expression?
Achieve precise control of gene expression with custom viral vectors designed for inducible systems such as Tet-On/Tet-Off. We provide end-to-end support—from construct design and plasmid preparation to viral packaging, purification, and quality control—ensuring tight regulation and robust induction. Optimized for both in vitro and in vivo use, our solutions deliver reliable and reproducible gene control.
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