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In Vivo Imaging
To enable real-time monitoring of biological processes, SignaGen offers a comprehensive portfolio of pre-made reporter vectors (e.g., AkaLuc, firefly luciferase, and EGFP) in adenoviral (AdV), adeno-associated viral (AAV), and lentiviral (LV) formats. These off-the-shelf products are produced at high titers and maintained in ready-to-use form, allowing rapid deployment for biodistribution, gene expression, and tumor-tracking studies. Select from vectors supplied for immediate transduction or transfection, or, if your specific requirements are not available, SignaGen can custom-design constructs or generate tailored viral vectors for advanced molecular in vivo imaging applications.
Off-the-shelf viral vectors for in vivo imaging
Bioluminescent Imaging Tools
Bioluminescence is widely used for in vivo imaging because it provides an exceptionally high signal-to-noise ratio. Mammalian tissues do not produce endogenous bioluminescence, resulting in essentially zero background signal
Fluorescent imaging Tools
Fluorescent imaging requires an external excitation light source (such as a laser or LED) to stimulate the reporter protein. A major limitation for in vivo applications is tissue autofluorescence, in which endogenous biomolecules emit background signal—particularly in the green spectrum—thereby reducing sensitivity
Genetically encoded calcium indicator (GECI)
Genetically encoded calcium indicators (GECI) like GCaMP6 & GCaMP8, etc, produce fluorescence in response to intracellular Ca²⁺ binding. Unlike synthetic dyes, GCaMP can be stably expressed from viral vectors or transgenes, enabling long-term, cell-type–specific monitoring of calcium dynamics. In neuroscience, GCaMP is widely used to visualize neuronal firing and synaptic activity in real time in living animals.
Custom viral vectors for in vivo imaging
Still can’t find the viral vectors you need for in vivo imaging in our off-the-shelf inventory? SignaGen offers custom viral vector development and production specifically tailored for in vivo imaging applications. Let our team design and manufacture the optimal imaging vector for your study, so you can focus on your research while we manage the technical details of vector construction and production.
AAV Production Full Service — SignaGen provides comprehensive, end-to-end recombinant AAV production full services, from gene synthesis and vector construction to delivery of in vivo–grade AAV vectors. We offer high-titer and ultra-high-titer preparations at production scales of up to 100 mL, achieving titers greater than 1 × 10¹³ VG/mL.
AAV Packaging Service — SignaGen offers recombinant AAV packaging services using customer-supplied AAV cis and trans plasmids, delivering in vivo–grade preparations at high and ultra-high titers. Production scales are available up to 100 mL, with titers exceeding 1 × 10¹³ VG/mL.
Lentivirus Production Full Service — SignaGen offers comprehensive, end-to-end lentivirus production, from gene synthesis and vector construction to delivery of in vivo–grade lentiviral vectors. We provide high-titer and ultra-high-titer preparations at scales of up to 5.0 mL, achieving titers greater than 1 × 10⁹ TU/mL.
Lentivirus Packaging Service — SignaGen provides lentivirus packaging services using customer-supplied lentivector plasmids, delivering in vivo–grade preparations at high and ultra-high titers. Production scales are available up to 5.0 mL, with titers exceeding 1 × 10⁹ TU/mL.
Interested in custom viral vectors for in vivo imaging?
SignaGen provides custom viral vector solutions for sensitive and reliable in vivo imaging. We design and produce AAV, lentiviral, and adenoviral vectors expressing fluorescent and bioluminescent reporters (e.g., GFP, mCherry, luciferase), optimized for tissue-specific expression and strong signal output. With high-titer production and rigorous QC, our vectors support real-time visualization of gene expression, cell tracking, and disease progression in diverse in vivo models.
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