In Vitro siRNA Transfection Reagents

SSmall interfering RNA (siRNA) is typically a ~21-nucleotide double-stranded RNA with two-nucleotide 3′ overhangs. When introduced into cells, a properly designed siRNA selectively silences a complementary target gene, making siRNA technology an essential tool for gene function studies and drug target validation.

Conventional lipid- and polymer-based reagents often deliver siRNA inefficiently because its short anionic structure forms unstable complexes with cationic carriers. Our proprietary pH-dependent conformational change (PDCC) technology uses pre-screened hydrophobic groups to improve lipoplex and polyplex stability. Based on this platform, we manufacture four siRNA transfection reagents with distinct performance advantages over leading commercial products.