Tough Decoy Design Strategy

 

Structures of decoy RNAs for miR140-3p. The bold black curved arrow represents the miRNA-binding site (MBS) (5′ → 3′). The red lines represent the linkers in these molecules. (A) Structure of the prototype-decoy RNA (Decoy RNA #001-006). (B) Structures of Decoy RNA #002 and #007-013. I, II, III and IV indicate the stems present in these molecules. The lengths of each stem sequence (I, II, III and IV) for the Decoy RNA panel are shown in Table 2. (C) Structures of Decoy RNA #018–022. The lengths of linker sequence for the Decoy RNA panel are shown in Table 4. (D) Structures of Decoy RNA #013, 020 and 023. The MBS sequence for the Decoy RNA panel are shown in Table 5.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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