The P41 and 40 promoters are the capsid gene promoters of different Adeno-Associated Virus (AAV) serotypes, driving the expression of the structural viral proteins (VP1, VP2, VP3). They exhibit key […]
Monthly Archives: November 2025
Cis-Acting Elements and Trans-Acting Factors on AAV2 Promoters
The three promoters are functionally interconnected through their shared regulatory elements, leading to the coordinated but hierarchical expression of AAV’s replication (Rep) and capsid (Cap) genes. Promoter Cis-Acting Elements (Key […]
Strength of AAV P5, P19 and P40 Promoters in Serotype 2
The AAV serotype 2 promoters P5, P19, and P40 exhibit a distinct hierarchy of strength during a productive lytic infection (i.e., in the presence of a helper virus like adenovirus, […]