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AAV9 VRs and their reported functional roles

AAV9 VRs and their reported functional roles.  Refer to http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393551

VR AAV9 aa Reported functional role(s) References
VR-I 262–269 Unknown in AAV9
VR-II 327–332 DE loop at the 5-fold channel; possible role in genome packaging
VR-III 382–386 Unknown in AAV9
VR-IV 452–460 aa 456–476, liver transduction efficiency determinant; aa 456-568, delayed blood clearance phenotype 37, 60
VR-V 488–505 aa 489–545 LamR receptor binding footprint; aa 498, 503, and 504, effect on liver- and muscle-specific transduction; aa 456-568, delayed-blood-clearance phenotype 2, 37, 60
VR-VI 527–539 aa 489–545, LamR receptor binding footprint; aa 456-568, delayed-blood-clearance phenotype 2, 37
VR-VII 545–558 aa 550–568, liver transduction efficiency determinant; aa 456-568, delayed blood clearance phenotype 37, 60
VR-VIII 581–593 aa 591–621, LamR receptor binding footprint: aa 582, 590, 592, transduction 2, 60
VR-IX 704–714 aa 699–735, determinant of heart tropism; determinant of improved melanoma tropism in chimeric virus, chimeric-1829; aa 706, mutants exhibited altered tropism 43

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