Ad-AMPK(DN)-GFP

$618.00

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  • Catalog #: SL100743
  • Unit Size: 1 x 0.2 ml

Product Category:
Human Adenovirus Type5 (dE1/E3) expressing 5' AMP-activated protein kinase (AMPK), dominant negative format under a CMV promoter with co-expression of a reporter GFP under a separate CMV promoter.

5' AMP-activated protein kinase or AMPK or 5' adenosine monophosphate-activated protein kinase is an enzyme that plays a role in cellular energy homeostasis. It consists of three subunits that together make a functional enzyme, conserved from yeast to humans. It is expressed in a number of tissues, including the liver, brain, and skeletal muscle. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation and ketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake, and modulation of insulin secretion by pancreatic beta-cells.

AMPK dominant negative form is used to genetically block effects of AMPK.
 




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