AAV2-mediated transduction of hepatocytes from normal C57BL/6 mice injected via tail vein with tyrosine-mutant capsid scAAV2-EGFP vectors. (A) Transgene expression was detected by fluorescence microscopy 2 weeks after injection of 1 × 1010 viral particles per animal via the tail vein (n = 2 per experimental group). (Magnification, ×50.) (B) Quantitation of the transduction efficiency in hepatocytes in C57BL/6 mice. *, P < 0.01 vs. WT scAAV2-EGFP.
Refer to Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7827-32.