Ad-CMV-FLPo

Price: $488.00

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  • Catalog #: SL101174
  • Unit Size: 1 x 200 µL

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Pre-made human adenovirus serotype 5 (dE1/E3), FLPo recombinase adenovirus; Ad-CMV-FLPo; Ad-FLPo

Product Category: Pre-made human adenovirus serotype 5 (dE1/E3), FLPo recombinase adenovirus; Ad-CMV-FLPo; Ad-FLPo

Description: FLP originally identified from Saccharomyces cerevisiae is a site-specific recombinases (SSR) from the λ integrase family and recognizes distinct 34 bp FRT sequence. It has been widely used for generating conditional knockout mice, mediated by FLP/FRT system. Initial use of FLP in mammalian cells revealed inefficient recombinase activity due to thermo-instability of the FLP protein. Subsequent screening for thermo-stable mutants resulted in the identification of FLPe which was 4-fold increase in recombination efficiency at 37 °C. However the recombination efficiency of FLPe in cells remains very low because of its non-mammalian origin.  

FLPo is a mouse codon optimized FLPe that greatly increases the FRT recombination efficiency for both in vivo and in vitro in mouse. 
This Ad-CMV-FLPo pre-packaged adenovirus over-expresses FLPo recombinase under CMV promoter.  Ready to use format.

Titer: 1x1010 ~ 1x1011 PFU/mL

Storage Buffer: DMEM with 2% BSA & 2.5% Glycerol

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Shuttle Vector Map:
Pre-made human adenovirus serotype 5 (dE1/E3), FLPo recombinase adenovirus; Ad-CMV-FLPo; Ad-FLPo




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