AAV-Syn-FLPo (AAV Serotype 1)

Price: $488.00

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  • Catalog #: SL101447
  • Unit Size: 1 x >30 L (>1E+13 VG/mL)

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Pre-made recombinant AAV; AAV-Synapsin-FLPo; AAV-Syn-FLPo; AAV1-Synapsin-FLPo; AAV1-Syn-FLPo

Product Category: Pre-made recombinant AAV; AAV-Synapsin-FLPo; AAV-Syn-FLPo; AAV1-Synapsin-FLPo; AAV1-Syn-FLPo

Description: FLP originally identified from Saccharomyces cerevisiae is a site-specific recombinases (SSR) from the λ integrase family and recognizes distinct 34 bp FRT sequence. It has been widely used for generating conditional knockout mice, mediated by FLP/FRT system. Initial use of FLP in mammalian cells revealed inefficient recombinase activity due to thermo-instability of the FLP protein. Subsequent screening for thermo-stable mutants resulted in the identification of FLPe which was 4-fold increase in recombination efficiency at 37 C. However the recombination efficiency of FLPe in cells remains very low because of its non-mammalian origin.  

FLPo is a mouse codon optimized FLPe that greatly increases the FRT recombination efficiency for both in vivo and in vitro in mouse. 
This AAV1-Synapsin-FLPo pre-made rAAV in serotype 1 (with capsid from AAV serotype 1 and 2xITR from AAV serotype 2) will over-express FLPo recombinase under human synapsin promoter (exclusive neuronal expression).  Ready to use format.

Titer: > 1x1013 VG/mL

Size: > 30 L (Std Pack)

Storage Buffer: PBS

Infection Protocol:

Vector Map:
Pre-made recombinant AAV; AAV-Synapsin-FLPo; AAV-Syn-FLPo; AAV1-Synapsin-FLPo; AAV1-Syn-FLPo




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